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The most promising for any modern researcher is to find a benefiting reply for herbal medicine, as they were criticized inthe past for their over advocacy of natural remedies. Such exploration in the modern research could be a dead end for million dollar business of synthetic drug around the globe.
Although the current status of herbal medicine is not restricted in developing countries of Central Asia, North Africa, South East Asia and Middle East, but its status has been strategically damaged by big corporate world of western medicine. On the contrary in developed countries, about 70% of all the medical doctors in France and Germany prescribe herbal medicines (Murray & Pizzorno, 2000). Unfortunately, for an anti-HIV treatment the
| western doctors advocate ART (a synthetic
chemical based drug) as this could be an
unkindliest cut of them towards natural remedies.
The herbal medicines stood the test of time for their efficacy, safety, non-toxicity, availability and economic acceptability. The phytochemicals present in them shows the better compatibility with the human body than the synthetic chemical drug. Also it is believed that their physicochemistry makes it safer for human body. Furthermore, the world health assembly of WHO adopted a resolution (WHA 42.43) in 1989 that herbal medicine is of great importance to the health of individual and communities. The herbal practitioners are to be blamed not the natural remedies for poor status of botanical drug.
| The natural medicines
kept the pace without being affected by the popularity of modern medicines. The major herbal pharma sector along with the
modern sector of pharma standardizes their herbal formulation by chromatography techniques like HPLC. Several hundred firms of small
sector are manufacturing herbal medicines with or without standardization, but till date none of the pharma has standardized herbal medicine
using active compound as marker linked with confirmation of bioactivity of herbal drug, this would be the prime reason for the unavailability of licensed
drug for HIV.
Recently, the French nobelist Dr. Luc Montaigner, who was awarded the Noble Prize for his prime role in the discovery for Human Immune Deficiency Virus (HIV), has recognized the acceptance of natural herbal medicine over modern medicine for HIV. He stated "the plants and natural products may hold the key to end the AIDS epidemic that has killed over 35 million", in a recent Indo-US health collaboration held in Mumbai. An 82 year old, noble prize winner virologist has clearly ruled out the effectiveness of vaccine for HIV. Furthermore, he pointed out the HIV a "smarter "virus than Ebola, as it induces antibodies but does not allow them to neutralize it.
Also he has proposed a "functional eradication" of the virus under the control of immune system
| and which is not harmful
anymore. So this could be a new start for the search of viral inhibitor protein with immune activation that has to be herbal based.
Montagnier emphasized on the fact that the world has "good tools" to fight the virus. He said "the tools are not only the western medicine, mostly
based on chemical, but also plants based natural product. India has a lot of experience in these natural remedies".
With the advent of HOOIMM PLUS (A, B, C, D, E) (an anti viral herb-drug manufactured by HOOTONE REMEDIES, have a composition of 35 different plant species those are found in India), which has recently gained public interest.
Many successful research have been done on it, reporting the presence of novel anti-HIV active compounds from plants and other natural product. A study says it found to contain anti-HIV active compounds that included Alkaloids, Terpenoids,
Quinones, Glycosides etc.
They also contain the high
phenolic content and the presence of polar substances,
such as flavonoids and tannins which
are known to possess antiviral activity. These
active compounds inhibited various steps in the
HIV life cycle. It inhibits HIV 1 protease, HIV 1 reverse
transcriptase, potently inhibit HIV replication,
inhibits the interaction between Gp 120 and
CD4 as a results, inactivates the viruses and blocks
the fusion of virus to the cell membrane, blocking
the initiation, promotion and progression.
HOO-IMM PLUS called unparalleled anti-HIV herb drug due to the absence of qualitative proviral DNA (LTR & GAG region), for the post treated HIV patients with HOO-IMM PLUS. GAG, the genomic region encoding the capsid protein. It gives rise to gag precursor protein P55 which is called assemblin, indicates its role in viral assembly. The P55 myristoylated protein, which is processed to P17(matrix), P24(capsid), P7(nucleocapsid) and P6 protein, by the viral protease. It associates with the plasma membrane, where virus assembly takes place. So this makes HOO-IMM PLUS an incomparable natural remedies.
Therefore stressing for the research for functional
cure for HIV has given rise to a new prospective
in the sphere for HIV cure by eradicating
the functioning viral genome that prevents the
viral assembly of the virus.
We have beeen courageous with our scientific
plant based drug approach towards HIV which not
only suppress the virus but also fasten up the
complete eradication of it, with no remission.